Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p047 | (1) | WCRB2014

Inhibition of DMRTA2 impairs human female germline development in xeno-grafted ovaries

Poulain Marine , Tourpin Sophie , Muczynski Vincent , Messiaen Sebastien , Moison Delphine , Duquenne Clotilde , Benachi Alexandra , Rouiller-Fabre Virginie , Habert Rene , Frydman Nelly , Livera Gabriel

Context: DMRTA2 belongs to a family of genes coding for proteins containing a DM-domain that are conserved among vertebrates and widely involved in gonadal differentiation. We recently identified Dmrta2 gene expression through transcriptome analysis performed in murine female embryonic germ cells and retrieved its expression in human fetal ovaries. The role of DMRTA2 is poorly documented and we thus conducted this study to clarify its implication in ...